Research advances on the role and mechanism of microRNA in hypertrophic scar / 中华烧伤杂志

Hypertrophic scar (HS) affects the function and beauty of patients, and brings a heavy psychological burden to patients. However, the specific pathogenesis mechanism of HS in molecular biology level is not yet clear, and this disease is still one of the clinical diseases difficult to prevent and cure. MicroRNA (miR) is a family of single-stranded endogenous noncoding RNAs that can regulate gene expression. The abnormal transcription of miR in hypertrophic scar fibroblasts can affect the transduction and expression of downstream signal pathway or protein, and the exploration of miR and its downstream signal pathway and protein helps deeply understand the occurrence and development mechanism of scar hyperplasia. This article summarized and analyzed how miR and multiple signal pathways involve in the formation and development of HS in recent years, and further outlined the interaction between miR and target genes in HS.

Effect of Abnormal Savda Munziq on hypertrophic scar formation in a rabbit ear model / 中国结合医学杂志

<p><b>OBJECTIVE</b>To investigate whether administrating Abnormal Savda Munziq (ASMq), a traditional Uighur herbal preparation used for the prevention or treatment of diseases, affects hypertrophic scar (HTS) formation by using an established rabbit ear model.</p><p><b>METHODS</b>The HTS rabbit model was created by circular fullthickness skin excisions on both ears of rabbits. Twenty rabbits were randomized into four groups, with 5 rabbits and 60 wounds in each group. Group A was the control group, treated with normal saline daily. Groups B, C, and D were the treatment groups at three different doses of ASMq (400, 800, and 1200 mg/kg body weight, respectively, daily, by gastrogavage). Twenty wounds were randomly chosen from each group on the 40th day after treatment and specimen were examined. Scar elevation index (SEI) was analyzed with histological assessment, and ultrastructure analysis was analyzed with a transmission electron microscopy.</p><p><b>RESULTS</b>Groups B, C, and D demonstrated significant reductions in SEI as compared with the control group at 35.9% (P=0.0212), 48.2% (P=0.0108), and 52.7% (P=0.0103), respectively in a dose-response manner. SEI was lowered in Group D compared with Group B with a significant difference (P=0.015). However, there were no significant differences between Groups B and C, or between Groups C and D. Histological analysis showed that highdose ASMq (1200 mg/kg) could enhance the softening of HTS of rabbit ears and increase the compliance as shown in general. Ultrastructure analysis showed that with increased ASMq dose, the fibroblasts, pro-collagen, collagen, endoplasmic reticulum and ribosomes were reduced gradually.</p><p><b>CONCLUSIONS</b>Orally administered ASMq significantly reduces the severity of HTS in the rabbit ear model. The findings of this study may have clinical implications on the management of human HTS.</p>

Effect of uighur medicine abnormal savda munzip on human hypertrophic scar fibroblasts in vitro / 中华整形外科杂志

<p><b>OBJECTIVE</b>To evaluate in vitro effect of abnormal savda munziq (ASMq) on the proliferation and apoptosis of human hypertrophic scar fibroblasts (HSFs).</p><p><b>METHODS</b>HSFs were divided into six groups to receive different treatments as group A (blank control group), group B-E (ASMq in different concentration), and group F(5-Fu). Each group contains six specimens. The HSFs were cultured in vitro. After culture for 48 hours, the CCK8 test and flow cytometry methods were used to detect the proliferation, cell cycle and apoptosis.</p><p><b>RESULTS</b>The proliferation of HSFs in the B, C, D and E groups was inhibited at G2/M period, while it was inhibited at G0/S period in group F (P < 0.05). The inhibition effect of ASMq (0.1-1.0 mg/ml) on the fibroblasts enhanced in a concentration-dependent manner. Flow cytometry analysis with annexin V-FITC and PI staining confirmed the apoptotic. When HSFs were exposed to ASMq at 1.0 mg/ml (group E) for 48 h, the percentage of apoptotic cells increased to (43.7 +/- 2.58)%, which was significantly higher than that of blank control group (2.2 +/- 0.59)%. The induced apoptosis effect was also increased in a concentration-dependent manner.</p><p><b>CONCLUSION</b>ASMq has a inhibitory effect on the proliferation and an enhancement effect on the apoptosis of fibroblast. ASMq could be used as an effective drug for treatment of hypertrophic scar.</p>

Capsular contracture in breast augmentation with textured versus smooth mammary implants: a systematic review / 中华整形外科杂志

<p><b>OBJECTIVE</b>To evaluate the incidence of capsular contracture in breast augmentation with textured versus smooth mammary Implants.</p><p><b>METHODS</b>Randomized controlled trials (RCTs) and clinical controlled trials (CCTs) were collected from Medline, Embase from May 1966 to May 2006, cochrane library (Issue 2, 2005), and CBM disc from May 1979 to May 2006. We handsearched Chinese Journal of Plastic Surgery (from establishment to May 2006) and Journal of Plastic and Reconstructive Surgery of America (from establishment to May 2006). RCTs were included. Data were extracted by two reviewers with designed extraction form RevMan. 4.2.8 software was used for data analysis.</p><p><b>RESULTS</b>Six RCTs were included. The combined results of meta analysis showed that patients with textured implants had a lower tendency to develop capsules contracture than those with smooth implants either at one year or ten years after the breast augmentation.</p><p><b>CONCLUSIONS</b>Compared with smooth mammary implants, textured surface implants significantly reduce the incidence of capsular contracture after breast augmentation.</p>

Community survey of plastic surgery / 中华整形外科杂志

<p><b>OBJECTIVE</b>A community survey was developed in order to analyses and assess the recognition of plastic surgery. And to provide some initial and useful evidence document for our other jobs.</p><p><b>METHODS</b>One thousand and one hundred individuals of various ages, either sex, different occupation and education levels, ethnically/racially diverse, social background, participated in this survey. All questionnaires were analyzed and chi-square analysis was performed for each question to compare the pattern of responses among the categories of respondents using the SPSS 11.5.</p><p><b>RESULTS</b>Nine hundred and forty six individuals completed the survey (overall response rate 86%). Group 1 consisted of 342 general college students; The second group consisted of 427 medical college students; the third included 129 general practitioners, and 48 members of the general public comprised the fourth group of respondents. The results reveal that the majority of the crowd in the four groups needs more information about the benefits that our specialty can offer them.</p><p><b>CONCLUSIONS</b>Despite the rapid progress that has occurred in the field of plastic surgery in the last 10 years, a large portion of the population is still unaware, even misunderstanding of the specialty. Therefore, they may not be taking advantage of the optimal care that is already available. And certainly, it also seriously hindrance the specialty. We should take effective methods to improve the advocacy from them. However, in our country, there is a scarcity of empirical evidence about the public perception of plastic surgery; this pilot study attempts to serve our jobs.</p>